Karma's Skill Max Order: Q → E → W
Matchup Tip: If Karma ever uses Q on the wave or misses her Q on you, instantly vault her and launch your combo on her. Even if Karma lands W root on you, she has no follow up damage and so you hard win the trade without her Q.
level 1: You can Quinn Cheese level 1 from the bush and then zone her off the wave. You win level 1 hard, but be careful of her empowered ability level 1. She will likely empower Q you, so try to side step after landing E if you can. if she misses this ability, then she is screwed.
level 2-5: If Karma Ws you, vault her + attack should help you escape it since you slow her with your E. Even though her E grants her more ms than your W does, your E slow + W proc is enough to escape it. I typically love fleet against Karma because you can escape her W almost every time with a fleet proc added on top of it. If Karma uses Q on the wave or if she misses it on you, instantly go in for a trade because that's her damage. Even if she lands her empowered W root on you, without her Q damage it is meaningless.
level 6+: There is no threat for her ult. Play the lane super aggro and run her down with trades whenever you get the opportunity to.
This matchup isn't common, but it is quite easy for Quinn.
It appears that her W root always hits you until about level 9.
You need boots rush in this matchup if you want to escape her W root.
If she roots you later, instantly E her, auto harrier, then run back to escape her W root.
If Karma ever Qs a minion or misses Q on you, instantly run her down becasue that's legit all her damage.
You must punish her every time she uses Q.
Do not sit there and farm, you have to punish her for this since it is free.
If she uses Q, instantly vault her then run her down for a big trade.
Even if she lands W root on you, without Q she does legit no damage.
Her empowered Q does a lot of damage, but the CD is 40 seconds so it isn't problematic.
Play behind minions so her Qs can't hit you as easily.